GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs4784054 | 1 | rs4784054 | chr16:58776314 | GOT2 | chr16:58741035-58768246:- | 0.19 | 3.81 | 0.000157 | Blood metabolite levels |
| THCA | cis | rs1362756 | 1 | rs4784295 | chr16:51471432 | SALL1 | chr16:51169886-51185183:- | 0.22 | 5.13 | 4.23E-7 | Optic disc area;Optic disc parameters |
| THCA | cis | rs4784934 | 1 | rs4784934 | chr16:58459926 | CCDC135 | chr16:57728713-57765366:+ | -0.21 | -3.9 | 0.000109 | QT interval |
| THCA | cis | rs4785204 | 1 | rs4785202 | chr16:50095995 | HEATR3 | chr16:50099881-50139373:+ | -0.4 | -6.49 | 2.13E-10 | Esophageal cancer (squamous cell) |
| THCA | cis | rs4785204 | 1 | rs4785203 | chr16:50096065 | HEATR3 | chr16:50099881-50139373:+ | -0.4 | -6.49 | 2.13E-10 | Esophageal cancer (squamous cell) |
| THCA | cis | rs4785204 | 1 | rs4785204 | chr16:50103734 | HEATR3 | chr16:50099881-50139373:+ | -0.37 | -5.83 | 1.02E-8 | Esophageal cancer (squamous cell) |
| THCA | cis | rs4785204 | 1 | rs4785379 | chr16:50089373 | HEATR3 | chr16:50099881-50139373:+ | -0.4 | -6.21 | 1.16E-9 | Esophageal cancer (squamous cell) |
| THCA | cis | rs8046148 | 1 | rs4785381 | chr16:50133789 | HEATR3 | chr16:50099881-50139373:+ | 0.33 | 6.91 | 1.52E-11 | Testicular germ cell tumor |
| THCA | cis | rs4787491 | 1 | rs4787491 | chr16:30015337 | FAM57B | chr16:30035749-30042186:- | -0.27 | -5.01 | 7.64E-7 | Body mass index |
| THCA | cis | rs4787491 | 1 | rs4787491 | chr16:30015337 | TBX6 | chr16:30097117-30103208:- | 0.2 | 4.68 | 3.7E-6 | Body mass index |
| THCA | cis | rs34286592 | 1 | rs4788187 | chr16:29845685 | MAPK3 | chr16:30125427-30134630:- | 0.23 | 3.48 | 0.000541 | Multiple sclerosis |
| THCA | cis | rs34286592 | 1 | rs4788187 | chr16:29845685 | MVP | chr16:29831787-29859342:+ | 0.12 | 3.46 | 0.000593 | Multiple sclerosis |
| THCA | cis | rs34286592 | 1 | rs4788188 | chr16:29860863 | MAPK3 | chr16:30125427-30134630:- | -0.24 | -3.52 | 0.00047 | Multiple sclerosis |
| THCA | cis | rs4788196 | 1 | rs4788196 | chr16:29967434 | FAM57B | chr16:30035749-30042186:- | -0.25 | -4.76 | 2.59E-6 | Pubertal anthropometrics |
| THCA | cis | rs4788196 | 1 | rs4788196 | chr16:29967434 | LOC595101 | chr16:30278914-30346695:- | -0.2 | -3.75 | 0.000198 | Pubertal anthropometrics |